A Short Overview on the Medicinal Chemistry of (—)-Shikimic Acid

Author(s): Amalia M. Estevez, Ramon J. Estevez.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 12 , Issue 14 , 2012

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Abstract:

Shikimic acid, a natural compound is a key intermediate in the biosynthesis of amino acids. Consequently, this derivative is widely present in many plants and has interesting biological properties. But besides the pharmacological relevance of shikimic acid itself, it is also an intermediate in the synthesis of many drugs, being the most relevant the antiviral agent oseltamivir (TamifluTM). Here we present a short overview on recent natural, biotechnological and synthetical sources of shikimic acid, togheter with pharmacological applications of this compound and a selection of derivatives, including oseltamivir (TamifluTM).

Keywords: Shikimic acid, natural products, biotechnology, Oseltamivir (TamifluTM), neuraminidase inhibitors, verum, Escherichia coli, Illicium verum, shikimic acid, Citrobacter freundii

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Article Details

VOLUME: 12
ISSUE: 14
Year: 2012
Page: [1443 - 1454]
Pages: 12
DOI: 10.2174/138955712803832735
Price: $58

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