Shikimic acid, a natural compound is a key intermediate in the biosynthesis of amino acids. Consequently, this
derivative is widely present in many plants and has interesting biological properties. But besides the pharmacological
relevance of shikimic acid itself, it is also an intermediate in the synthesis of many drugs, being the most relevant the
antiviral agent oseltamivir (TamifluTM). Here we present a short overview on recent natural, biotechnological and
synthetical sources of shikimic acid, togheter with pharmacological applications of this compound and a selection of
derivatives, including oseltamivir (TamifluTM).
Keywords: Shikimic acid, natural products, biotechnology, Oseltamivir (TamifluTM), neuraminidase inhibitors, verum, Escherichia coli, Illicium verum, shikimic acid, Citrobacter freundii
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