Carbohydrate Mimics and Lectins: A Source of New Drugs and Therapeutic Opportunities

Author(s): Jose J. Reina, Anna Bernardi.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 12 , Issue 14 , 2012

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Abstract:

Mimics of oligosaccharides capable of interfering with lectin activity are currently being pursued by a number of groups in an effort to produce tools for glycobiology and to design antagonists of medically relevant lectins. The field is reviewed in this chapter. After a brief overview of the state of the art, examples from our and others’ studies on the dendritic cell receptor DC-SIGN are illustrated.

Keywords: Carbohydrates, glycomimetics, C-type lectins and DC-SIGN, Pseudomonas aeruginosa, LECTINS, carbohydrate-encoded, high-mannose, oligosaccharides

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Article Details

VOLUME: 12
ISSUE: 14
Year: 2012
Page: [1434 - 1442]
Pages: 9
DOI: 10.2174/138955712803832690
Price: $58

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