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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Carbohydrate Mimics and Lectins: A Source of New Drugs and Therapeutic Opportunities

Author(s): Jose J. Reina and Anna Bernardi

Volume 12, Issue 14, 2012

Page: [1434 - 1442] Pages: 9

DOI: 10.2174/138955712803832690

Price: $65

Abstract

Mimics of oligosaccharides capable of interfering with lectin activity are currently being pursued by a number of groups in an effort to produce tools for glycobiology and to design antagonists of medically relevant lectins. The field is reviewed in this chapter. After a brief overview of the state of the art, examples from our and others’ studies on the dendritic cell receptor DC-SIGN are illustrated.

Keywords: Carbohydrates, glycomimetics, C-type lectins and DC-SIGN, Pseudomonas aeruginosa, LECTINS, carbohydrate-encoded, high-mannose, oligosaccharides


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