Abstract
Flavonoids, secondary metabolites ubiquitously produced in the plant kingdom, are low molecular weight polyphenolic molecules. They are characterized by variable chemical structures and show a vast array of biological activities (i.e... antiviral, antiinflammatory, antitumor, antimicrobial, estrogenic, antiestrogenic, antioxidant, mutagenic and antimutagenic) targeting different pathways. Some of these compounds such as Genistein, Daidzein or its synthetic derivative Phenoxodiol as well as Luteolin and Quercetin are able to inhibit DNA topoisomerases. This review discusses that Flavonoids targeting DNA topoisomerases may lead to novel drug development with anticancer potential.
Keywords: Cell death, clinical trials, DNA topoisomerases, DNA topoisomerases poisoning, drug discovery and development, flavonoids, phenoxodiol, systems Biology, therapeutic agents, Luteolin
Current Medicinal Chemistry
Title:Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy
Volume: 19 Issue: 31
Author(s): P. Russo, A. Del Bufalo and A. Cesario
Affiliation:
Keywords: Cell death, clinical trials, DNA topoisomerases, DNA topoisomerases poisoning, drug discovery and development, flavonoids, phenoxodiol, systems Biology, therapeutic agents, Luteolin
Abstract: Flavonoids, secondary metabolites ubiquitously produced in the plant kingdom, are low molecular weight polyphenolic molecules. They are characterized by variable chemical structures and show a vast array of biological activities (i.e... antiviral, antiinflammatory, antitumor, antimicrobial, estrogenic, antiestrogenic, antioxidant, mutagenic and antimutagenic) targeting different pathways. Some of these compounds such as Genistein, Daidzein or its synthetic derivative Phenoxodiol as well as Luteolin and Quercetin are able to inhibit DNA topoisomerases. This review discusses that Flavonoids targeting DNA topoisomerases may lead to novel drug development with anticancer potential.
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Cite this article as:
Russo P., Del Bufalo A. and Cesario A., Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy, Current Medicinal Chemistry 2012; 19 (31) . https://dx.doi.org/10.2174/092986712803833272
DOI https://dx.doi.org/10.2174/092986712803833272 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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