Differentiated Thyroid Carcinoma and Intestinal Polyposis Syndromes

Author(s): Vincenzo Triggiani, Vito Angelo Giagulli, Angela Tafaro, Francesco Resta, Carlo Sabba, Brunella Licchelli, Edoardo Guastamacchia.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Volume 12 , Issue 4 , 2012

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Abstract:

Familial Adenomatous Polyposis, Cowden’s Syndrome, and Peutz-Jeghers Syndrome are well known as Intestinal Polyposis Syndromes, inherited conditions characterized by the development of polyps of the gastro-intestinal tract in association with extra-intestinal manifestations, in particular malignant tumors at different sites. Thyroid carcinoma is sometimes a part of the clinical picture of these syndromes. The aim of this paper is to review the literature dealing with the association between differentiated thyroid carcinomas and Intestinal Polyposis Syndromes in order to point out peculiar aspects, providing suggestions for the screening and the management of thyroid tumors in these patients.

Keywords: Cowden’s syndrome, differentiated thyroid carcinoma, familial adenomatous polyposis, follicular thyroid carcinoma, intestinal polyposis syndromes, papillary thyroid carcinoma, peutz-jeghers syndrome, multiple hamartoma syndrome, colorectal carcinoma, Ret-PTC rearrangements, Associated non-cutaneous malignancies, Prophylactic thyroidectomy.

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Article Details

VOLUME: 12
ISSUE: 4
Year: 2012
Page: [377 - 381]
Pages: 5
DOI: 10.2174/187153012803832558
Price: $65

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