Differentiated Thyroid Carcinoma and Intestinal Polyposis Syndromes

Vincenzo      Triggiani; Vito      Angelo Giagulli; Angela      Tafaro; Francesco      Resta; Carlo      Sabba; Brunella      Licchelli; Edoardo      Guastamacchia

Abstract

Familial Adenomatous Polyposis, Cowden’s Syndrome, and Peutz-Jeghers Syndrome are well known as Intestinal Polyposis Syndromes, inherited conditions characterized by the development of polyps of the gastro-intestinal tract in association with extra-intestinal manifestations, in particular malignant tumors at different sites. Thyroid carcinoma is sometimes a part of the clinical picture of these syndromes. The aim of this paper is to review the literature dealing with the association between differentiated thyroid carcinomas and Intestinal Polyposis Syndromes in order to point out peculiar aspects, providing suggestions for the screening and the management of thyroid tumors in these patients.

Keywords: Cowden’s syndrome, differentiated thyroid carcinoma, familial adenomatous polyposis, follicular thyroid carcinoma, intestinal polyposis syndromes, papillary thyroid carcinoma, peutz-jeghers syndrome, multiple hamartoma syndrome, colorectal carcinoma, Ret-PTC rearrangements, Associated non-cutaneous malignancies, Prophylactic thyroidectomy.