With the current advances in genomics and proteomics, cardiovascular molecular imaging techniques such as
PET and SPECT, in combination with other cardiac molecular imaging techniques, will identify new markers of disease
activity and will play a central role in screening of patients, diagnosis, prognosis and patient management.
The complexity of the development process of vulnerable atherosclerotic plaques provides an excellent example of the
need for combined molecular imaging. Predicting outcome by molecular imaging of atherosclerotic plaques should offer
new paradigms for the management of coronary artery disease. In cardiac neurotransmission, molecular imaging can offer
insights and provide better understanding of pathophysiologic mechanisms and help to improve patient management, in
particular in patients with heart failure or at risk of arrhythmias. A recent important advance in the area of cardiovascular
molecular imaging is reporter gene imaging. The concept has been validated in animal models, where reporter genes are
only expressed by living stem cells, offering a means to track stem cell survival. Reporter genes are passed on to daughter
cells, making assessment of cell proliferation possible. Reporter gene imaging can be applied to a variety of stem cells or
therapeutic genes of interest in stem cell or gene based therapy in cardiovascular medicine.