Lipids and Lysosomes

Author(s): Isabelle Hamer, Guillaume Van Beersel, Thierry Arnould, Michel Jadot.

Journal Name: Current Drug Metabolism

Volume 13 , Issue 10 , 2012


Abstract:

Lysosomes are cytoplasmic organelles delimited by a single membrane and filled with a variety of hydrolytic enzymes active at acidic pH and collectively capable to degrade the vast majority of macromolecules entering lysosomes via endocytosis, phagocytosis or autophagy. In this review, we describe the lipid composition and the dynamic properties of lysosomal membrane, the main delivery pathways of lipids to lysosomes and their catabolism inside lysosomes. Then, we present the consequences of a lipid accumulation as seen in various lysosomal storage diseases on lysosomal functions. Finally, we discuss about the possible involvement of lysosomes in lipotoxicity.

Keywords: Lipids, lysosomes, lysosomal hydrolysis and lysosomal trafficking

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Article Details

VOLUME: 13
ISSUE: 10
Year: 2012
Page: [1371 - 1387]
Pages: 17
DOI: 10.2174/138920012803762684
Price: $58

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