Abstract
Fourteen novel compounds were obtained and their chemical structures were established by 1H-NMR and IR spectra as well as elemental analyses. As one of the most important factors determining the changes of activity of respective fluorophenyl and iodophenyl derivatives, one should consider the volume of halogen substituent and its influence on the lipophilicity of the entire molecule.
Keywords: Aminomethylation, Drug-resistance, Hydroxymethylation, s-triazoles, 1, 2, 4-triazole derivatives, N2-aminomethyl/hydroxymethyl derivative, N4-aryl moiety, Staphylococcus aureus, Elemental analyses, N4-(4-fluorophenyl)
Letters in Drug Design & Discovery
Title:Halogen Substituents as an Effective Modulators of Antibacterial Activity of Substituted 1,2,4-triazole-3-thiones
Volume: 9 Issue: 10
Author(s): Tomasz Plech, Monika Wujec, Urszula Kosikowska and Anna Malm
Affiliation:
Keywords: Aminomethylation, Drug-resistance, Hydroxymethylation, s-triazoles, 1, 2, 4-triazole derivatives, N2-aminomethyl/hydroxymethyl derivative, N4-aryl moiety, Staphylococcus aureus, Elemental analyses, N4-(4-fluorophenyl)
Abstract: Fourteen novel compounds were obtained and their chemical structures were established by 1H-NMR and IR spectra as well as elemental analyses. As one of the most important factors determining the changes of activity of respective fluorophenyl and iodophenyl derivatives, one should consider the volume of halogen substituent and its influence on the lipophilicity of the entire molecule.
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Cite this article as:
Plech Tomasz, Wujec Monika, Kosikowska Urszula and Malm Anna, Halogen Substituents as an Effective Modulators of Antibacterial Activity of Substituted 1,2,4-triazole-3-thiones, Letters in Drug Design & Discovery 2012; 9 (10) . https://dx.doi.org/10.2174/1570180811209050947
DOI https://dx.doi.org/10.2174/1570180811209050947 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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