Background: We believe that the frequent treatment failure with patients with eating disorders is in part due to
the heterogeneity of patients with this diagnosis and to an incomplete understanding of psychopathological factors
relevant to prognosis and treatment planning for subgroups of patients.
Goals: This ongoing study aimed to investigate the existence of psychopathologically significant dimensions in a sample
of patients with Eating Disorders (EDs), using the Operationalized Psychodynamic Diagnosis (OPD-2) system (OPD Task
Methods: The sample included 50 consecutive non-selected young women (mean age 19, [SD = 2,6] years old) attending a
Nutrition Day Hospital at the Eating Disorder Unit of the Niguarda Hospital, Milan, who were evaluated by an OPD-2
trained interviewer. We performed two different factor analyses with the Oblimin rotation: the first one using OPD Axis I
(Experience of Illness) variables, and the second using factors taken from Axis I and Axis III (Conflicts) and Axis IV
Conclusions: In the first analysis, we obtained four different psychodynamic dimensions, that we called Explicit Illness
Configurations (EICs), that represent the patient’s psychological, somatic and social theory of illness and a symptomatic
dimension. In the second analysis, we discovered three recurrent psychodynamic dimensions, which we called Implicit
Functioning Profile (IFPs), representing more stable organizations of illness that may contribute to the high outcome
variability in this disorder. These results suggest the existence of different subgroups of patients with EDs differing from
each other with respect to psychodynamic features. These data suggest that tailoring therapeutic approaches to the
patients’ individual profiles could improve outcomes.