In the last two decades a tremendous development has been noticed in our understanding of the purinergic system, consisting
of heterogeneously expressed purinoceptor subtypes and its classical agonists: e.g., adenosine triphosphate, uridine triphosphate or complex
dinucleoside polyphosphates. These agonists exert multiple effects on the vascular system: they regulate the relaxation and constriction
of arterial blood vessels, lead to proliferation and migration in endothelial cells and vascular smooth muscle cells, and mediate potent
proinflammatory responses or phenotypic cell changes. This review focuses on the P2 purinoceptor subtype P2Y and its pleiotropic effects
in the vascular wall under physiological and pathophysiological condition. Various experimental and clinical studies provide evidence
that pharmacological targeting of P2Y might be effective in reducing vascular alterations under disease conditions.
Keywords: Dinucleoside polyphoshates, nucleotides, purinoceptors, P2Y, vascular disease, purinergic system, agonists, proliferation, migration, endothelial cells.
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