Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Discovery of novel therapeutic opportunities
for EOC is important for the improvement of clinical outcome of the patients. Emerging evidence is suggesting
that epithelial-mesenchymal transition (EMT) plays a crucial role in the aggressiveness in EOC including increasing migration
and invasion ability, contributing to chemoresistance and cancer stem cell populations. Targeting EMT in EOC
thus offers an attractive therapeutic option.
Keywords: Epithelial-mesenchymal transition, ovarian cancer, Epithelial-mesenchymal transition, ovarian cancer, chemoresistance, motile mesenchymal cells, cnidarian species, embryonic epithelia, Drosophila embryos, Twist, Snail, tumor cells
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