Abstract
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Discovery of novel therapeutic opportunities for EOC is important for the improvement of clinical outcome of the patients. Emerging evidence is suggesting that epithelial-mesenchymal transition (EMT) plays a crucial role in the aggressiveness in EOC including increasing migration and invasion ability, contributing to chemoresistance and cancer stem cell populations. Targeting EMT in EOC thus offers an attractive therapeutic option.
Keywords: Epithelial-mesenchymal transition, ovarian cancer, Epithelial-mesenchymal transition, ovarian cancer, chemoresistance, motile mesenchymal cells, cnidarian species, embryonic epithelia, Drosophila embryos, Twist, Snail, tumor cells
Current Drug Targets
Title:Targeting Pathways Contributing to Epithelial-Mesenchymal Transition (EMT) in Epithelial Ovarian Cancer
Volume: 13 Issue: 13
Author(s): Ruby Yun-Ju Huang, Vin Yee Chung and Jean Paul Thiery
Affiliation:
Keywords: Epithelial-mesenchymal transition, ovarian cancer, Epithelial-mesenchymal transition, ovarian cancer, chemoresistance, motile mesenchymal cells, cnidarian species, embryonic epithelia, Drosophila embryos, Twist, Snail, tumor cells
Abstract: Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Discovery of novel therapeutic opportunities for EOC is important for the improvement of clinical outcome of the patients. Emerging evidence is suggesting that epithelial-mesenchymal transition (EMT) plays a crucial role in the aggressiveness in EOC including increasing migration and invasion ability, contributing to chemoresistance and cancer stem cell populations. Targeting EMT in EOC thus offers an attractive therapeutic option.
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Cite this article as:
Yun-Ju Huang Ruby, Yee Chung Vin and Paul Thiery Jean, Targeting Pathways Contributing to Epithelial-Mesenchymal Transition (EMT) in Epithelial Ovarian Cancer, Current Drug Targets 2012; 13 (13) . https://dx.doi.org/10.2174/138945012803530044
DOI https://dx.doi.org/10.2174/138945012803530044 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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