Targeting Pathways Contributing to Epithelial-Mesenchymal Transition (EMT) in Epithelial Ovarian Cancer

Author(s): Ruby Yun-Ju Huang, Vin Yee Chung, Jean Paul Thiery.

Journal Name: Current Drug Targets

Volume 13 , Issue 13 , 2012

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Abstract:

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Discovery of novel therapeutic opportunities for EOC is important for the improvement of clinical outcome of the patients. Emerging evidence is suggesting that epithelial-mesenchymal transition (EMT) plays a crucial role in the aggressiveness in EOC including increasing migration and invasion ability, contributing to chemoresistance and cancer stem cell populations. Targeting EMT in EOC thus offers an attractive therapeutic option.

Keywords: Epithelial-mesenchymal transition, ovarian cancer, Epithelial-mesenchymal transition, ovarian cancer, chemoresistance, motile mesenchymal cells, cnidarian species, embryonic epithelia, Drosophila embryos, Twist, Snail, tumor cells

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Article Details

VOLUME: 13
ISSUE: 13
Year: 2012
Page: [1649 - 1653]
Pages: 5
DOI: 10.2174/138945012803530044
Price: $65

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