Cancer progression and metastasis involve series of alterations in the expression of multitude of genes. The
structure and organization of chromatin play an important role in spatial arrangement of genes inside the nucleus thereby
allowing different machineries to activate or silence the transcription of genes governed by various epigenetic events.
Epigenetic modifications and dynamic changes in chromatin organization by organizer proteins have recently been shown
to play an instrumental role in regulating cancer-promoting genes. Special AT-rich binding protein (SATB1) is a unique
type of global regulator that integrates higher-order chromatin organization with regulation of gene expression. Aberrant
expression of SATB1 has been shown to promote breast, hepatocellular, prostate and various other cancers. In this review
we highlight upon the role of SATB1in chromatin organization and as global regulator of gene expression during cancer
development. The expression of SATB1 progressively increases with the progression of cancers and it dynamically reprograms
the expression of genes that are involved in epithelial-mesenchymal transition. SATB1 directly regulates the expression
of ERRB2, MMP2, ABL1, E-cadherin and hence acts as key regulator in cancer development. Understanding the
molecular mechanisms of regulation of SATB1 expression would therefore be extremely essential towards designing
strategies to control it. Recent studies have provided important insights into regulation of SATB1 by FOXP3 and microRNAs.
In this review we evaluate the potential of SATB1 as molecular target for cancer therapy.
Keywords: SATB1, chromatin organization, epigenetic modifications, metastasis, Wnt signaling, gene regulation, SATB1, chromatin organization, epigenetic modifications, metastasis, Wnt signaling, gene regulation., Cancer progression, ERRB2, FOXP3, microRNAs,
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