Regulation of DNA Replication Licensing

Author(s): Hiroyuki Niida, Masatoshi Kitagawa.

Journal Name: Current Drug Targets

Volume 13 , Issue 13 , 2012

Abstract:

In eukaryotic cells, DNA replication is tightly regulated to occur only once per cell cycle. DNA licensing is a mechanism to guarantee this aim; that is, licensing of replication initiation is permitted during late M phase to G1 phase. The license is canceled by the start of DNA replication. Once DNA replication begins, the license is never given until the next late M phase. The licensing corresponds to the process of assembling components of the pre-replication complex (pre-RC) on the replication origin DNA. This pre-RC is the target of several different regulation systems to prevent rereplication of DNA during a single cell cycle. In this review, the regulation mechanisms mainly in mammals to control assembling components of the pre-RC will be discussed.

Keywords: CDC10-dependent transcript 1 (CDT1), cell division cycle 6 (CDC6), DNA replication, high mobility group AThook 1 (HMGA1), histone acetyltransferase binding to ORC (HBO1), homeobox protein Hox-D13 (HOXD13), licensing, mini chromosome maintenance (MCM), origin recognition complex (ORC), prereplication complex (pre-RC), CDC10-dependent transcript 1 (CDT1), cell division cycle 6 (CDC6), DNA replication, high mobility group AThook1 (HMGA1), histone acetyltransferase binding to ORC (HBO1), homeobox protein Hox-D13 (HOXD13), licensing, mini chromosome maintenance (MCM), origin recognition complex (ORC), prereplication complex (pre-RC)

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Article Details

VOLUME: 13
ISSUE: 13
Year: 2012
Page: [1588 - 1592]
Pages: 5
DOI: 10.2174/138945012803529965
Price: $58

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