One-Step Synthesis of 1,2,5-Trisubstituted Pyrroles by Copper Catalyzed Condensation of 1,4-Diones with Primary Amines

Author(s): Rapelli Srinivas, Boningari Thirupathi, J. K. Prashanth Kumar, Avvari N. Prasad, Benjaram M. Reddy.

Journal Name: Current Organic Chemistry

Volume 16 , Issue 20 , 2012

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Abstract:

Highly dispersed copper iodide on activated carbon (CuI/C) solid catalyst has been investigated for the Paal–Knorr condensation of γ-diketones with aliphatic, aromatic and heterocyclic amines under solvent-free conditions; which lead to the formation of N- substituted pyrrole derivatives in excellent yields. This simple experimental procedure combined with easy recovery and reusability of the catalyst is expected to contribute to the progression of a clean and ecofriendly strategy for the synthesis of N-substituted pyrrole derivatives.

Keywords: CuI/C, Heterogeneous catalyst, Paal–Knorr condensation, N-Substituted pyrroles, Solvent-free, Montmorillonite, anhydrous Na2SO4, N-substituted pyrroles, substituents, hexadecylamine.

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Article Details

VOLUME: 16
ISSUE: 20
Year: 2012
Page: [2482 - 2489]
Pages: 8
DOI: 10.2174/138527212803520182
Price: $58

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