Current Vascular Pharmacology

Dimitri P. Mikhailidis  
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG
UK

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Mechanisms of Diabetic Dyslipidemia: Relevance for Atherogenesis

Author(s): Marcello Arca, Giovanni Pigna, Carla Favoccia.

Abstract:

Diabetic dyslipidemia is due to a multiple array of metabolic abnormalities determining a typical phenotype characterized by increased plasma triglycerides, reduced HDL and a preponderance of small, dense LDL. This dyslipidemia, defined as atherogenic dyslipidemia, is thought to be highly responsible for the increased cardiovascular risk in diabetes mellitus. Several lines of evidence indicate that the increased liver production of VLDL is the main underlying defect in atherogenic dyslipidemia. This review will recapitulate the pathophysiological aspects of diabetic dyslipidemia with special focus on the molecular mechanism causing increased liver production of VLDL in diabetic patients. The consequences of atherogenic dyslipidemia on mechanisms of atherogenesis will be also reviewed.

Keywords: Atherogenic dyslipidemia, VLDL secretion, apoB metabolism, insulin resistance

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Article Details

VOLUME: 10
ISSUE: 6
Year: 2012
Page: [684 - 686]
Pages: 3
DOI: 10.2174/157016112803520864