An Efficient One-Step Synthesis of 1H-pyrazolo[3,4-b]pyridines in Basic Ionic Liquid [bmim]OH

Author(s): Ling-ling Zhao, Yu Wan, Hai-ying Wang, Chao Wang, Xiao-xiao Zhang, Shu-ying Huang, Gui-xiang Liu, Liang-feng Chen, Hui Wu.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 9 , 2012

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Abstract:

Chain 1,3-dicarbonyl compounds were firstly used as starting material to react with 5-amino-3-methyl-1- phenylpyrazol and aromatic aldehydes to prepare 1H-pyrazolo[3,4-b]pyridines in basic ionic liquid [bmim]OH. The onestep three-component reaction is simple and efficient. Additionally, water was the only one by-product during the whole process.

Keywords: Basic ionic liquid, pyrazolo[3, 4-b]pyridines, infertility, addiction, symptoms, inhibitors, three-component reaction, pKa, steric hindrance, recrystallized

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Article Details

VOLUME: 9
ISSUE: 9
Year: 2012
Page: [671 - 676]
Pages: 6
DOI: 10.2174/157017812803521144
Price: $65

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