An Efficient Ultrasound Promoted One-Pot Three-Component Synthesis and Antibacterial Activities of Novel Pyrimido[4,5-b]quinoline- 4,6(3H,5H,7H,10H)-dione Derivatives

Author(s): Maryam S. Jourshari , Manouchehr Mamaghani , Khalil Tabatabaeian , Farhad Shirini , Mehdi Rassa , Hadiss Langhari .

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 9 , 2012

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Abstract:

A series of novel pyrimido[4,5-b]quinoline-4,6(3H,5H,7H,10H)-dione derivatives was synthesized by one-pot three-component reaction of the appropriate aldehyde, dimedone or cyclohexanedione and 6-aminothiouracil in ethanol under ultrasonic irradiation at 50 oC in short reaction times (1.5-3 min) and excellent yields (94-99%). The antibacterial activities of the synthesized compounds were evaluated on M. leuteus, B. subtilis, E. coli and Ps. aeruginosa. All the synthesized products showed good antibacterial activities.

Keywords: 6-aminothiouracil, antibacterial, MCR, one-pot, pyrimido[4, 5-b]quinolone, pyridopyrimidine, pyrazole, ultrasound, synthesis, yields

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Article Details

VOLUME: 9
ISSUE: 9
Year: 2012
Page: [664 - 670]
Pages: 7
DOI: 10.2174/157017812803521207
Price: $58

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