Abstract
A series of novel pyrimido[4,5-b]quinoline-4,6(3H,5H,7H,10H)-dione derivatives was synthesized by one-pot three-component reaction of the appropriate aldehyde, dimedone or cyclohexanedione and 6-aminothiouracil in ethanol under ultrasonic irradiation at 50 oC in short reaction times (1.5-3 min) and excellent yields (94-99%). The antibacterial activities of the synthesized compounds were evaluated on M. leuteus, B. subtilis, E. coli and Ps. aeruginosa. All the synthesized products showed good antibacterial activities.
Keywords: 6-aminothiouracil, antibacterial, MCR, one-pot, pyrimido[4, 5-b]quinolone, pyridopyrimidine, pyrazole, ultrasound, synthesis, yields
Letters in Organic Chemistry
Title:An Efficient Ultrasound Promoted One-Pot Three-Component Synthesis and Antibacterial Activities of Novel Pyrimido[4,5-b]quinoline- 4,6(3H,5H,7H,10H)-dione Derivatives
Volume: 9 Issue: 9
Author(s): Maryam S. Jourshari, Manouchehr Mamaghani, Khalil Tabatabaeian, Farhad Shirini, Mehdi Rassa and Hadiss Langhari
Affiliation:
Keywords: 6-aminothiouracil, antibacterial, MCR, one-pot, pyrimido[4, 5-b]quinolone, pyridopyrimidine, pyrazole, ultrasound, synthesis, yields
Abstract: A series of novel pyrimido[4,5-b]quinoline-4,6(3H,5H,7H,10H)-dione derivatives was synthesized by one-pot three-component reaction of the appropriate aldehyde, dimedone or cyclohexanedione and 6-aminothiouracil in ethanol under ultrasonic irradiation at 50 oC in short reaction times (1.5-3 min) and excellent yields (94-99%). The antibacterial activities of the synthesized compounds were evaluated on M. leuteus, B. subtilis, E. coli and Ps. aeruginosa. All the synthesized products showed good antibacterial activities.
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S. Jourshari Maryam, Mamaghani Manouchehr, Tabatabaeian Khalil, Shirini Farhad, Rassa Mehdi and Langhari Hadiss, An Efficient Ultrasound Promoted One-Pot Three-Component Synthesis and Antibacterial Activities of Novel Pyrimido[4,5-b]quinoline- 4,6(3H,5H,7H,10H)-dione Derivatives, Letters in Organic Chemistry 2012; 9 (9) . https://dx.doi.org/10.2174/157017812803521207
DOI https://dx.doi.org/10.2174/157017812803521207 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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