A series of chiral oxazolidines derived from (1R, 2S)-cis-1-amino-2-indanol was found to be effective in
promoting the asymmetric addition of diethylzinc to aldehydes. Among the ligands developed, it was found that ligand 1b
in the presence of Ti(OiPr)4 yielded the highest enantioselectivities when it was applied in the catalytic asymmetric addition
of diethylzinc to aldehydes (up to 91% ee).
Keywords: Asymmetric alkynylation, enantioselectivity oxazolidine, secondary alcohol, Chiral, dialkylzinc reagents, schlenk tube, organic layer, UV detection, Aldrich, chelating group
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