Synthesis and Application of Novel Dithiane Alcohol Ligand Based on Chiral Cyclopropane-backbone for Asymmetric Ethylation of Aromatic Aldehydes

Author(s): Risong Na , Bo Wang , Honglei Liu , Qinghua Bian , Jiangchun Zhong , Min Wang , Hongchao Guo .

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 9 , 2012

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Abstract:

A novel chiral dithiane alcohol ligand, based on chiral cyclopropane-backbone, was easily prepared from (–)- 1R-cis-caronaldehyde. The chiral ligand was used in asymmetric ethylation of aromatic aldehydes to afford the corresponding secondary alcohols with moderate to good enantioselectivity.

Keywords: Asymmetric, cyclopropane-backbone, chiral ligand, diethylzinc addition, dithiane alcohol, catalysis, structurally diverse, enantioselectivities, potential, Bruker Tensor 27 spectrometer

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Article Details

VOLUME: 9
ISSUE: 9
Year: 2012
Page: [622 - 627]
Pages: 6
DOI: 10.2174/157017812803521171
Price: $58

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