Neovascularization, which may play a pivotal role in physiological and pathological conditions such as rheumatoid
arthritis (RA), is a complex process involving endothelial cell division, selective degradation of vascular basement
membranes and the surrounding extracellular matrix, and endothelial cell migration. The involvement of several endogenous
molecules has been suggested based on the ability of these molecules to regulate the proliferation of endothelial
cells. There are a number of factors that regulate angiogenic and angiostatic functions and may be crucial in promoting
neovascularization, including vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), angiopoietins
and members of the chemokine family, such as CXCL8 and CXCL10. This review discusses the expression and regulation
of angiogenic and angiostatic cytokines in the context of chronic inflammatory arthritis, such as RA.
Keywords: Angiogenesis, angiopoietin, angiostatin, antigen-induced arthritis, chemokines, collagen-induced arthritis, CXCL8,
CXCL10, endostatin, endothelial cell, fibroblast growth factor, IL-18, neovascularization, platelet-derived growth factor receptor,
rheumatoid arthritis, vascular endothelial growth factor.
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