The aim of the presented work describes the formulation of compressed orally disintegrating tablet (ODT) using
α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as a binder/disintegrant. Preliminary investigations were focused
on process and formulation optimisation which resulted in ODT containing 2% wt. TPGS with reasonable hardness
and acceptable disintegration time but with high friability. The next stage of the work was to systematically investigate
various strategies to overcome high friability including hot-cold cycle of powder blending to promote interparticular adhesion,
size separation of diluent, influence of compression force and incorporation of crospovidone. The study concluded
that friability was controlled by multi-strategic approach which resulted in reduction from 3.16% to 1%.
Keywords: Direct compression, orally disintegrating tablets, friability, interparticulate, mannitol, particle size, morphology, dysphagia, paediatric, geriatric, pharmaceutical, freeze drying, meticulous, synchronisation, α-tocopheryl.
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