The Seemingly Trivial Yet Challenging Synthesis of Poly(aminoester) Dendrimers

Author(s): Y. Wang, G. Quelever, L. Peng.

Journal Name: Current Medicinal Chemistry

Volume 19 , Issue 29 , 2012

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Abstract:

Poly(aminoester) dendrimers are expected to hold great promise as biodegradable nanocarriers for drug delivery due to their advantageous properties allowing their biodegradability, potentially lower toxicity and possibility of diverse chemical conjugations. The synthetic strategies for constructing such dendrimers include the amine branching method, the ester formation method, the combination of both methods as well as the recently emerging click chemistry based synthesis. We present here an overview on the current state of synthesizing poly(aminoester) dendrimers and discuss the benefits and limitations of each strategy with a view to stimulating a fueled interest in the development of efficient and reliable methodologies to synthesize such dendrimers.

Keywords: Biodegradable dendrimer, click chemistry, dendrimer, drug delivery, nanocarriers, poly(aminoester)

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Article Details

VOLUME: 19
ISSUE: 29
Year: 2012
Page: [5011 - 5028]
Pages: 18
DOI: 10.2174/0929867311209025011
Price: $58

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