Glucagon Like Peptide-1 and Atherosclerosis

Author(s): Tomoya Mita, Hirotaka Watada.

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry

Volume 10 , Issue 4 , 2012

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Abstract:

Patients with type 2 diabetes mellitus are at high risk for developing cardiovascular diseases. Traditional medicines for type 2 diabetes, such as sulfonylureas, pioglitazone, and insulin have glucose lowering effects; however, they also increase the frequency of hypoglycemia and/or body weight and thus may cancel out the benefits of glucose lowering on the development of atherosclerosis. In contrast, the recently developed glucagon like peptide-1-based therapy using glucagon-like peptide-1 receptor agonists or dipeptidyl peptidase-4 inhibitors has numerous beneficial effects in the management of hyperglycemia with less risk of hypoglycemia and weight gain. Glucagon-like peptide-1-based therapy also lowers blood pressure and blood lipids and thus may prevent progression of atherosclerosis. Furthermore, glucagonlike peptide-1 receptors are abundantly expressed in vascular cells such as endothelial cells, monocyte/macrophages and smooth muscle cells. Recent studies suggest that the anti-inflammatory and vasodilatory properties of glucagon-like peptide-1 signaling on endothelial cells, its anti-inflammatory effect on macrophages and anti-proliferative effects on smooth muscle cells may halt atherosclerosis. Although large clinical trials are required to confirm these beneficial effects, glucagon-like peptide-1-based therapy could provide both glucose lowering and protection against cardiovascular diseases in patients with type 2 diabetes.

Keywords: Atherosclerosis, diabetes, endothelial cells, glucagon-like peptide-1, macrophage/monocyte, smooth muscle cells

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2012
Page: [309 - 318]
Pages: 10
DOI: 10.2174/187152512803530388
Price: $58

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