Abstract
Objective: Present work focuses on the use of tamarind gum to develop a drug delivery system making combined use of floating and pulsatile principles, for the chrono-prevention of nocturnal acid breakthrough. Method: The desired aim was achieved by fabricating a floating delivery system bearing time – lagged coating of Tamarindus indica seed polymer for the programmed release of Famotidine. Response Surface Methodology was the statistical tool that was employed for experiment designing, mathematical model generation and optimization study. A 32 full factorial design was used in designing the experiment. % weight ratio of tamarind gum to ethyl cellulose in the coating combination and the coating weight were the independent variables, whereas the lag time for drug release and the cumulative % drug release in 330 minutes were the observed responses. Key findings: Results revealed that both the coating composition and the coating weight significantly affected the release of drug from the dosage form. Conclusion: The optimized formulation prepared according to the computer generated software, Design-Expert® deciphered response which were in close proximity with the experimental responses, thus confirming the robustness and accuracy of the predicted model for the utilization of natural polymer like tamarind gum for the chronotherapeutic treatment of nocturnal acid breakthrough.
Keywords: Chrono-prevention, Nocturnal acid breakthrough, Response Surface Methodology, Full factorial design
Current Drug Delivery
Title:Design and Optimization of a Chronotherapeutic Dosage Form for Treatment of Nocturnal Acid Breakthrough
Volume: 9 Issue: 6
Author(s): Vaibhav Agarwal and Mayank Bansal
Affiliation:
Keywords: Chrono-prevention, Nocturnal acid breakthrough, Response Surface Methodology, Full factorial design
Abstract: Objective: Present work focuses on the use of tamarind gum to develop a drug delivery system making combined use of floating and pulsatile principles, for the chrono-prevention of nocturnal acid breakthrough. Method: The desired aim was achieved by fabricating a floating delivery system bearing time – lagged coating of Tamarindus indica seed polymer for the programmed release of Famotidine. Response Surface Methodology was the statistical tool that was employed for experiment designing, mathematical model generation and optimization study. A 32 full factorial design was used in designing the experiment. % weight ratio of tamarind gum to ethyl cellulose in the coating combination and the coating weight were the independent variables, whereas the lag time for drug release and the cumulative % drug release in 330 minutes were the observed responses. Key findings: Results revealed that both the coating composition and the coating weight significantly affected the release of drug from the dosage form. Conclusion: The optimized formulation prepared according to the computer generated software, Design-Expert® deciphered response which were in close proximity with the experimental responses, thus confirming the robustness and accuracy of the predicted model for the utilization of natural polymer like tamarind gum for the chronotherapeutic treatment of nocturnal acid breakthrough.
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Cite this article as:
Agarwal Vaibhav and Bansal Mayank, Design and Optimization of a Chronotherapeutic Dosage Form for Treatment of Nocturnal Acid Breakthrough, Current Drug Delivery 2012; 9 (6) . https://dx.doi.org/10.2174/156720112803529756
DOI https://dx.doi.org/10.2174/156720112803529756 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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