Alginate based Hydrogel as a Potential Biopolymeric Carrier for Drug Delivery and Cell Delivery Systems: Present Status and Applications

Author(s): Tapan Kumar Giri, Deepa Thakur, Amit Alexander, Ajazuddin, Hemant Badwaik, Dulal Krishna Tripathi.

Journal Name: Current Drug Delivery

Volume 9 , Issue 6 , 2012

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Abstract:

Alginate is a non-toxic, biocompatible and biodegradable natural polymer with a number of peculiar physicochemical properties for which it has wide applications in drug delivery and cell delivery systems. Hydrogel formation can be obtained by interactions of anionic alginates with multivalent inorganic cations by simple ionotropic gelation method. Hydrophilic polymeric network of three dimensional cross linked structures of hydrogels absorb substantial amount of water or biological fluids. Among the numerous biomaterials used for hydrogel formation alginate has been and will continue to be one of the most important biomaterial. Therefore, in view of the vast literature support, we focus in this review on alginate - based hydrogel as drug delivery and cell delivery carriers for biomedical applications. Various properties of alginates, their hydrogels and also various techniques used for preparing alginate hydrogels have been reviewed.

Keywords: Alginate, hydrogels, drug delivery, cell delivery, bovine serum albumin, diclofenac sodium

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2012
Page: [539 - 555]
Pages: 17
DOI: 10.2174/156720112803529800
Price: $58

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PDF: 52