Gluten-dependent Intestinal Autoimmune Response

Author(s): Ilma Rita Korponay-Szabo, Zsofia Simon-Vecsei, Luigina De Leo, Tarcisio Not.

Journal Name: Current Pharmaceutical Design

Volume 18 , Issue 35 , 2012

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Abstract:

Celiac disease is a multi-systemic autoimmune disease of the small bowel induced by gluten in genetically predisposed subjects. Highly specific and gluten-dependent production of auto-antibodies targeting self-proteins of the transglutaminase family occurs in the intestinal mucosa. These anti-transglutaminase antibodies are found deposited in intestinal and extra-intestinal tissue where they might exert biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. We conducted a brief review on antitransglutaminase antibodies effects, discussing their roles in the pathogenesis of several clinical manifestations of celiac disease.

Keywords: Genetic gluten intolerance, intestinal anti-transglutaminase antibodies, auto-immunity

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Article Details

VOLUME: 18
ISSUE: 35
Year: 2012
Page: [5753 - 5758]
Pages: 6
DOI: 10.2174/138161212803530826
Price: $58

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