Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Targeting Basal-Like Breast Cancers

Author(s): Nandini Dey, Brian R. Smith and B. Leyland-Jones

Affiliation: Edith Sanford Breast Cancer, Sanford Research/University of South Dakota.

Keywords: Basal-like breast cancers, BRCA1/2 incompetency, PARP inhibitors, PTEN, pathway targeted inhibitors, triple negative breast cancer, gene-expression data profiles, TNBC phenotype, epithelial growth factor receptor [EGFR], breast basal-epithelial cells.

Abstract:

Basal-like breast tumors and triple negative breast tumors are high-risk breast cancers that typically carry the poorest prognoses compared with HR (Hormone Receptor)-positive tumors and HER2 (Human Epidermal growth factor Receptor 2)-amplified tumors for known therapies. These subsets of breast cancers exhibit aggressive clinical behavior, pushing margins of invasion, poor clinical outcome, and derive limited benefit from current therapy. This clinical situation is contributed and further aggravated by their less known biology, lack of obvious molecular targets, absence of favorable biomarkers, and their limited response to single-drug therapy. In 2010, Oakman et al., remarked that current therapy fails to curtail the innate aggressive behavior of TNBC (Triple Negative Breast Cancer) in the majority of patients. The poor prognosis coupled with a lack of targeted use of therapies is responsible for the high mortality in this subtype. The present review will examine the existing literature and scrutinize the difficulties that have, to date, limited the understanding of the biology of these tumor cells, and provide a rationale for the development of the concept of combining subtype-specific and pathway-specific drug targets for the therapeutic intervention of the disease.

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Article Details

VOLUME: 13
ISSUE: 12
Page: [1510 - 1524]
Pages: 15
DOI: 10.2174/138945012803530116