This review treats the recent patents and related literature, mainly from the Authors laboratories, on biomedical
and food packaging applications of nano-composites constituted of biodegradable polymers filled with micro or nano
crystals of organically modified Layered Double Hydroxides of Hydrotalcite type. After a brief outline of the chemical
and structural aspects of Hydrotalcite-like compounds (HTlc) and of their manipulation via intercalation of functional molecular
anions to obtain materials for numerous, sometime unexpected applications, the review approaches the theme in
three separated parts.
Part 1 deals with the synthetic method used to prepare the pristine Mg-Al and Zn-Al HTlc and with the procedures of their
functionalization with anti-inflammatory (diclofenac), antibacterial (chloramphenicol hemisuccinate), antifibrinolytic
(tranexamic acid) drugs and with benzoates with antimicrobial activity. Procedures used to form (nano) composites of
polycaprolactone, used as an example of biodegradable polymer, and functionalized HTlc are also reported.
Part 2 discusses a patent and related papers on the preparation and biomedical use of a controlled delivery system of the
above mentioned pharmacologically active substances. After an introduction dealing with the recent progress in the field
of local drug delivery systems, the chemical and structural aspects of the patented system constituted of a biodegradable
polymer and HTlc loaded with the active substances will be presented together with an extensive discussion of the drug
release in physiological medium.
Part 3 deals with a recent patent and related papers on chemical, structural and release property of antimicrobial species of
polymeric films containing antimicrobial loaded HTlc able to act as active packaging for food products prolonging their
Keywords: Antimicrobial activity, antibiotic activity, active food packaging, biomedical application, barrier properties, benzoate
derivatives, composites, chloramphenicol hemisuccinate, drug release, diclofenac, hydrotalcites, kinetics, layered double
hydroxides, mechanical properties, nano-hybrids, polycaprolactone, tranexamic acid
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