Preparation, Physicochemical Evaluation and Antimicrobial Potential of Topical Dosage Forms Containing Natural Anti-inflammatory Agent, Curcuma longa
Ngai Kok Leong,
Lim Wen Bin,
In an attempt for better treatment of bacterial infections and burn wounds various topical
formulations containing 1%w/w of Curcuma longa were prepared and evaluated for physical appearance, pH,
rheological properties and stability studies. Antimicrobial activity of prepared formulations was found to be
more effective against various strains of bacteria. Carbopol gel base is the most suitable dermatological base
for Curcuma longa in comparison to various other dermatological bases. It also has aesthetic appeal, which
other bases lack, an important aspect from patient compliance and consumer point of view. The therapeutic
potential of such topical formulations may motivate researchers for its further exploitation so that it may be
commercially viable. This innovative mode of formulation of Curcuma longa can be employed for enhancing
the anti-microbial effect.
Keywords: Curcuma longa, topical, antimicrobial, polyethylene glycol, Dimethylformamide, Hydroxypropyl methyl cellulose, Topical route, semisolid formulations, carbopol gel base, dermatological base.
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