Multiple Roles of Histamine in Autoimmune Demyelinating Disease of the Central Nervous System
Histamine is a biogenic amine with a broad spectrum of activities in various physiological and
pathological conditions. Beside its well characterized effects in allergic responses and acute inflammation,
histamine modulates the cytokine network, influencing T helper 1 and T helper 2 balance and antibody isotype.
In multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE),
there are several steps in the autoimmune attack against myelin of the central nervous system where histamine
has been shown to play important roles. In this review, we summarize the evidences supporting the hypothesis
of a significant contribution for histamine in autoimmune demyelinating diseases of the central nervous system.
A deeper appreciation of the mechanisms by which histamine regulates the development of EAE and MS
might have relevance in the therapy of these diseases.
Keywords: Blood-brain barrier, cytokines, experimental autoimmune encephalomyelitis, histamine, multiple sclerosis,
T cells, central nervous system, Interleukin, Histamine receptor, PHARMACOLOGICAL STUDIES.
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