Activatable fluorescent probes share the unique feature of being turned on only under specific conditions: they are "silent"
when not interacting with a specific target protein, microenvironment, or reactive species. Several activatable fluorescence probes have
demonstrated their potential in cell biology study, disease study and diagnosis, and even in the rapidly expanding field of image-guided
surgery. In this review, we will summarize progress in the design of activatable probes and their application in studying cell biology or in
optical imaging. Some of the most effective examples of activatable fluorescent probes will be presented and their application will be
Keywords: Activatable fluorescent probes, cancer imaging, FRET, metal ions, neurodegenerative diseases, optical imaging, photon-induced
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