Activatable Fluorescent Probes: A New Concept in Optical Molecular Imaging

Author(s): E. Lacivita, M. Leopoldo, F. Berardi, N. A. Colabufo, R. Perrone.

Journal Name: Current Medicinal Chemistry

Volume 19 , Issue 28 , 2012

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Abstract:

Activatable fluorescent probes share the unique feature of being turned on only under specific conditions: they are "silent" when not interacting with a specific target protein, microenvironment, or reactive species. Several activatable fluorescence probes have demonstrated their potential in cell biology study, disease study and diagnosis, and even in the rapidly expanding field of image-guided surgery. In this review, we will summarize progress in the design of activatable probes and their application in studying cell biology or in optical imaging. Some of the most effective examples of activatable fluorescent probes will be presented and their application will be discussed.

Keywords: Activatable fluorescent probes, cancer imaging, FRET, metal ions, neurodegenerative diseases, optical imaging, photon-induced electron transfer

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Article Details

VOLUME: 19
ISSUE: 28
Year: 2012
Page: [4731 - 4741]
Pages: 11
DOI: 10.2174/092986712803341511
Price: $58

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PDF: 21