Abstract
αA- and αB-crystallins, the major lens structure proteins and members of the small heat-shock proteins (sHSPs) family, play essential roles in maintaining normal cellular structure and physiology of both ocular and some non-ocular tissues. Mutations and abnormal expression of these sHSPs are associated with various human diseases such as cataract, neural disorders, and cardiovascular diseases. In addition, recent studies have revealed that the abnormal expressions and functions of both α-crystallins are associated with several types of tumors. In this regard, αA- and αB-crystallins seem to function differentially or even oppositely during tumorigenesis, and diverse molecular mechanisms have been proposed to explain their roles in cell apoptosis, cell proliferation and tumor metastasis. In this review, we have summarized the current status regarding the expression patterns and functions of αA- and αB-crystallins implicated in tumorigenesis, and discussed the possible mechanisms underlying their functions.
Keywords: αA-/αB-crystallin, apoptosis, cancer, lens, metastasis, pancreas, tumor, tumorigenesis, mutations, cataract, cardiac muscle, chaperones, denaturation, cytoskeletons, heat-shock proteins
Current Molecular Medicine
Title:Alpha-Crystallins and Tumorigenesis
Volume: 12 Issue: 9
Author(s): P. Chen, W. Ji, F.-Y. Liu, H.-Z. Tang, S. Fu, X. Zhang, M. Liu, L. Gong, M. Deng, W.-F. Hu, X.-H. Hu, X.-W. Chen, Z.-L. Li, X. Li, J. Liu and D.W.-C. Li
Affiliation:
Keywords: αA-/αB-crystallin, apoptosis, cancer, lens, metastasis, pancreas, tumor, tumorigenesis, mutations, cataract, cardiac muscle, chaperones, denaturation, cytoskeletons, heat-shock proteins
Abstract: αA- and αB-crystallins, the major lens structure proteins and members of the small heat-shock proteins (sHSPs) family, play essential roles in maintaining normal cellular structure and physiology of both ocular and some non-ocular tissues. Mutations and abnormal expression of these sHSPs are associated with various human diseases such as cataract, neural disorders, and cardiovascular diseases. In addition, recent studies have revealed that the abnormal expressions and functions of both α-crystallins are associated with several types of tumors. In this regard, αA- and αB-crystallins seem to function differentially or even oppositely during tumorigenesis, and diverse molecular mechanisms have been proposed to explain their roles in cell apoptosis, cell proliferation and tumor metastasis. In this review, we have summarized the current status regarding the expression patterns and functions of αA- and αB-crystallins implicated in tumorigenesis, and discussed the possible mechanisms underlying their functions.
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Chen P., Ji W., Liu F.-Y., Tang H.-Z., Fu S., Zhang X., Liu M., Gong L., Deng M., Hu W.-F., Hu X.-H., Chen X.-W., Li Z.-L., Li X., Liu J. and Li D.W.-C., Alpha-Crystallins and Tumorigenesis, Current Molecular Medicine 2012; 12 (9) . https://dx.doi.org/10.2174/156652412803306747
DOI https://dx.doi.org/10.2174/156652412803306747 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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