Malignant glioma remains a disease with poor prognosis despite recent advances in the multidisciplinary care
of this disease. Herein we review the evolution of and recent advances in radiation therapy for malignant glioma that have
allowed for more targeted therapy, potentially improving efficacy while decreasing normal tissue toxicity. Current and
emerging techniques are presented, including stereotactic radiotherapy and radiosurgery, brachytherapy, radioimmunotherapy,
and charged particle therapy, as well as the combination of these modalities with novel targeted biochemotherapies.
Keywords: Brachytherapy, charged particle therapy, glioma, radiotherapy, radiosurgery, radioimmunotherapy, biochemotherapies, Glioblastoma multiforme (GBM), radiosensitizers, CT scans
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