The assessment of percutaneous absorption of molecules is a very important step in the evaluation of any dermal or transdermal
drug delivery system. In order to perform percutaneous drug absorption studies, it is essential that the methods are standardized and
that the integrity of the skin is monitored and maintained to ensure that the data obtained are valid and relevant. Reproducible data on
percutaneous absorption in humans are as well required to predict the systemic risk from dermal exposure to chemicals, such as hazardous
substances at the workplace, agrochemicals and cosmetic ingredients. In vitro and animal models provide important tools for screening
a series of drug formulations, evaluation of skin permeation enhancing properties and mechanism of action of the carrier systems and
estimation of rank of skin transport for a series of drug molecules. In this review, we have summarized in vitro testing of skin absorption
using static Franz-type diffusion cells.
Keywords: Absorption, dermal, diffusion cell, Franz cell, in vitro, penetration, percutaneous, permeation, skin, transdermal delivery.
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