Design of Peptidomimetic Based DPP-IV Inhibitors, Devoid of CYP Liabilities
Shailesh R. Shah,
Kalapatapu V.V.M. Sairam,
A peptidomimetic based cyanopyrrolidine derivatives are reported as potent and selective DPP-IV inhibitors.
Some of the test compounds (10l and 10m) showed excellent potency and selectivity towards DPP-IV over various serine
proteases, without CYP inhibition.
Keywords: CYP, cyanopyrrolidine, DPP-IV inhibitors, Selectivity, Peptidomimetic
Rights & PermissionsPrintExport