Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Design of Peptidomimetic Based DPP-IV Inhibitors, Devoid of CYP Liabilities

Author(s): Pradip Jadav, Rajesh Bahekar, Shailesh R. Shah, Dipam Patel, Amit Joharapurkar, Kiran Shah, Shruti Bhardwaj, Kishan Patel, Kaushil Patel, Rajendra Chopade, Mubeen Shaikh, Kalapatapu V.V.M. Sairam, Mukul Jain.

Abstract:

A peptidomimetic based cyanopyrrolidine derivatives are reported as potent and selective DPP-IV inhibitors. Some of the test compounds (10l and 10m) showed excellent potency and selectivity towards DPP-IV over various serine proteases, without CYP inhibition.

Keywords: CYP, cyanopyrrolidine, DPP-IV inhibitors, Selectivity, Peptidomimetic

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Article Details

VOLUME: 9
ISSUE: 9
Year: 2012
Page: [867 - 873]
Pages: 7
DOI: 10.2174/157018012803307932
Price: $58