Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


The Synergistic Antibacterial Effects of Water Soluble N-succinyl-chitosan with Ceftriaxone against Escherichia coli

Author(s): Zhihui Luo, Qingsheng Wu, Meng Zhang.


In this paper, the antibacterial activity of N-succinyl-chitosan (NSCS) synthetized via N-acetylation on the chitosan (CS) by succinic anhydride was investigated. Diameter of inhibition zone (DIZ) measurement and colonyforming capability assay showed that the antimicrobial effects of NSCS varied along with the reaction time, and reaction for 4h would bring the best efficacy to the NSCS against Escherichia coli (E. coli). And the ceftriaxone could achieve synergistic antibacterial actions with NSCS rather than the raw CS dissolved in the HAc. The infrared ray (IR) and ultraviolet-visible (UV-vis) spectrum indicated that the NSCS and ceftriaxone assembled to a stable antibacterial group and inhibit the E. coli jointly. These results demonstrated the potential efficacy of CS in combinations with antibiotics for enhancing total biological activity.

Keywords: Bacteria, Ceftriaxone, Mechanism, N-succinyl-chitosan, Synergistic antibacterial effects, Water-solubility

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Article Details

Year: 2012
Page: [848 - 852]
Pages: 5
DOI: 10.2174/157018012803307905
Price: $58