Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Antibacterial Characterization of 1-benzoyl-4-arylthiosemicarbazides and the study of their structure-activity relationship

Author(s): Edyta Kusmierz, Agata Siwek, Urszula Kosikowska, Anna Malm, Monika Wujec.

Abstract:

Series of 1-benzoyl-4-arylthiosemicarbazides were efficiently synthesized and evaluated for their antibacterial activities. The results indicated that most of the compounds possessed activity against the Gram-positive bacterial species. Some structural and electronic parameters have been determined to explore the correlation between the biological activity and structure. The molecular study suggests that inhibitory action of studied thiosemicarbazides towards Gram-positive bacterial species is connected with electronic parameters rather than the geometry of the molecule.

Keywords: Antibacterial activity, Structure-activity relationship (SAR) studies, Thiosemicarbazide derivatives

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Article Details

VOLUME: 9
ISSUE: 9
Year: 2012
Page: [828 - 832]
Pages: 5
DOI: 10.2174/157018012803307914
Price: $58