Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

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Novel Piperazinyl Derivatives with Anti-Hyperalgesic, Anti-Allodynic and Anti-Inflammatory activities Useful for the Treatment of Neuropathic Pain

Author(s): Monika Sharma, Shraddha Suman Dash, Gangadhar Matharasala, Vanamala Deekshith, Dharmarajan Sriram, Perumal Yogeeswari.

Abstract:

A series of structurally novel compounds possessing 2-phenylpiperazin-1-yl nicotinamide template was synthesized and evaluated for neuropathic pain activity. After the assessment of neurotoxicity and peripheral analgesic activity, the compounds were evaluated in a peripheral neuropathic pain model, the chronic constriction injury (CCI) to assess their antiallodynic and antihyperalgesic potential. Studies carried out to assess the underlying mechanism revealed that the compounds (5 and 6) suppressed the inflammatory component of the neuropathic pain and inhibited oxidative and nitrosative stress.

Keywords: Neuropathic pain, antiallodynic, antihyperalgesic, carrageenan, nitric oxide, DPPH

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2012
Page: [182 - 190]
Pages: 9
DOI: 10.2174/187152312803305704
Price: $58