Application of Small Molecules/Macromolecules in Ocular Inflammatory Diseases
Robert B. Nussenblatt.
Macrobiomolecular treatments for ocular inflammatory diseases have been described in a previous review. This
article mainly discusses the application of small molecules in uveitis therapy, which includes corticosteroids, salicylic acid
(aspirin), metabolite analogs, and anti-oxidative agents. Additionally, we update recent advances in peptide and nucleic
acid related therapies, and focus mainly on the calcineurin inhibitor, cyclosporine, oral tolerant retinal proteins/peptides,
gene therapy and ribonucleic acid interference strategies. We classify these immunomodulatory agents by their molecular
signatures and highlight the molecular structure and mechanisms of function. These developments in understanding molecular
mechanisms of the diseases, with the advent of new technologies, advance current therapeutic approaches. The future
direction is to tailor treatments to individual patients in order to provide the safest and most effective therapies for
ocular inflammatory diseases.
Keywords: Uveitis, macrobiomolecule, small molecule, immunosuppresion, anti-inflammation
Rights & PermissionsPrintExport