Generic placeholder image

Current Genomics

Editor-in-Chief

ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Chromatin Remodeling, DNA Damage Repair and Aging

Author(s): Baohua Liu, Raymond K.H Yip and Zhongjun Zhou

Volume 13, Issue 7, 2012

Page: [533 - 547] Pages: 15

DOI: 10.2174/138920212803251373

Price: $65

Abstract

Cells are constantly exposed to a variety of environmental and endogenous conditions causing DNA damage, which is detected and repaired by conserved DNA repair pathways to maintain genomic integrity. Chromatin remodeling is critical in this process, as the organization of eukaryotic DNA into compact chromatin presents a natural barrier to all DNA-related events. Studies on human premature aging syndromes together with normal aging have suggested that accumulated damages might lead to exhaustion of resources that are required for physiological functions and thus accelerate aging. In this manuscript, combining the present understandings and latest findings, we focus mainly on discussing the role of chromatin remodeling in the repair of DNA double-strand breaks (DSBs) and regulation of aging.

Keywords: Aging, Longevity, Epigenetics, Sirtuins, Histone modifications, DNA double strand break repair


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy