Description of High Purity and High Specific Activity of [11C]Choline Synthesis Using TRACERlab FXc Module, and Detailed Report of Quality Controls

Author(s): Giorgio Biasiotto, Francesco Bertagna, Ugo Biasiotto, Carlo Rodella, Giovanni Bosio, Luigi Caimi, Giovanni Bettinsoli, Raffaele Giubbini.

Journal Name: Medicinal Chemistry

Volume 8 , Issue 6 , 2012

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Abstract:

We proposed a method of synthesis to produce [11C]Choline using TRACERlab FXc module that utilized gas phase iodination. The product had radiochemical purity of 99.79 + 0.14 % and specific activity of 45.7 + 7.59 GBq/mol. [11C]Choline did not have at the moment a specific monograph in European Pharmacopeia therefore we used, when possible, as quality controls reference the monograph of [18F]FDG and we proposed suitable methods to verify radiochemical purity and to quantify residual DMAE and choline amounts.

Keywords: [11C]CH3I, [11C]Choline, gas phase iodination, prostate cancer, PET, quality controls, radiopharmaceutical, TRACERlab FXc

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Article Details

VOLUME: 8
ISSUE: 6
Year: 2012
Page: [1182 - 1189]
Pages: 8
DOI: 10.2174/1573406411208061182
Price: $58

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