Synthesis of 2-(4-substitutedbenzylpiperazin-1-yl)-N-(2-oxo-2,3-dihydrobenzooxazol- 6-yl)acetamides as Inotropic Agents

Author(s): Tianyi Zhang, Liangpeng Sun, Xuekun Liu, Xun Cui, Huri Piao.

Journal Name: Medicinal Chemistry

Volume 8 , Issue 6 , 2012

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Abstract:

We describe the synthesis and positive inotropic evaluation of a series of 2-(4-substitutedbenzylpiperazin-1-yl)- N-(2-oxo-2,3-dihydrobenzooxazol-6-yl)acetamides by measuring left atrial stroke volume in preparations of isolated rabbit hearts. Several compounds were developed from and showed favorable activities compared with the standard drug milrinone. Compound 4l was the most potent with an increased stroke volume of 11.78 ± 0.18% (milrinone 6.36 ± 0.13%) at 1  10–4 M in our in-vitro study. The chronotropic effects of compounds having inotropic effects were also evaluated.

Keywords: 2, 3-Dihydro-2-oxobenzo[d]oxazole, Positive inotropic activity, Stroke volume

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Article Details

VOLUME: 8
ISSUE: 6
Year: 2012
Page: [1093 - 1098]
Pages: 6
DOI: 10.2174/1573406411208061093
Price: $58

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