Abstract
The use of ultrasound in therapeutic medicine is a developing field. The action of many anticancer agents can be improved with the use of ultrasonic exposure either in vitro or in vivo. Boron-based compounds have shown promising results as chemotherapeutic agents in specific forms of cancer. We synthesized a new boron compound of chloroacetohydroxamic acid, 2-hydroxyamino-oxoethylborate (HAOB). HAOB was used in combination with ultrasound (US) at a frequency of 25 KHz, and inhibitory effects on the growth of mouse ascites tumours were monitored by observing survival time, tumour growth, cell viability and DNA synthesis of treated Ehrlich ascites carcinoma (EAC) cells. 5-Fluorouracil (5- FU) was used as a positive control. The results indicated that HAOB alone produced significant antitumor action whereas combination of US with HAOB or 5-FU produced an extra antitumor action when compared to the actions of HAOB or 5- FU used alone.
Keywords: Boron compound, HAOB, Ultrasound, EAC, Antitumor, 5-FU
Medicinal Chemistry
Title:Enhancement of Antitumor Effects of a New Boron Compound Combined with Ultrasound on the Mouse Ascites Tumor
Volume: 8 Issue: 6
Author(s): Pradip Ghosh, Pratima Sur and Saswati P. Bag
Affiliation:
Keywords: Boron compound, HAOB, Ultrasound, EAC, Antitumor, 5-FU
Abstract: The use of ultrasound in therapeutic medicine is a developing field. The action of many anticancer agents can be improved with the use of ultrasonic exposure either in vitro or in vivo. Boron-based compounds have shown promising results as chemotherapeutic agents in specific forms of cancer. We synthesized a new boron compound of chloroacetohydroxamic acid, 2-hydroxyamino-oxoethylborate (HAOB). HAOB was used in combination with ultrasound (US) at a frequency of 25 KHz, and inhibitory effects on the growth of mouse ascites tumours were monitored by observing survival time, tumour growth, cell viability and DNA synthesis of treated Ehrlich ascites carcinoma (EAC) cells. 5-Fluorouracil (5- FU) was used as a positive control. The results indicated that HAOB alone produced significant antitumor action whereas combination of US with HAOB or 5-FU produced an extra antitumor action when compared to the actions of HAOB or 5- FU used alone.
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Cite this article as:
Ghosh Pradip, Sur Pratima and P. Bag Saswati, Enhancement of Antitumor Effects of a New Boron Compound Combined with Ultrasound on the Mouse Ascites Tumor, Medicinal Chemistry 2012; 8 (6) . https://dx.doi.org/10.2174/1573406411208061026
DOI https://dx.doi.org/10.2174/1573406411208061026 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
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