A new series of phenyl- and heteryl acetamidines were synthesized and evaluated as inhibitors of nitric oxide
synthases (NOS). While the N-substitution of the acetamidine moiety with different heterocycles appears to completely
destroy the activity, linking the phenyl core preserves it. Moreover, it was observed a strong dependence of the phenylacetamidines
potency of action from the length of the alkyl chain that connects the aromatic ring to the acetamidine moiety.
Keywords: Nitric oxide, Nitric oxide synthase, Selective inducible NOS inhibitors, Acetamidines, heterocycles, inorganic, neurodegenerative diseases, cytokines, polysaccharides, amino acid
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