Selective Inhibition of Inducible Nitric Oxide Synthase by Derivatives of Acetamidine

Author(s): Cristina Maccallini, Antonia Patruno, Alessandra Ammazzalorso, Barbara De Filippis, Marialuigia Fantacuzzi, Sara Franceschelli, Letizia Giampietro, Simona Masella, Maria Luisa Tricca, Rosa Amoroso.

Journal Name: Medicinal Chemistry

Volume 8 , Issue 6 , 2012

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Abstract:

A new series of phenyl- and heteryl acetamidines were synthesized and evaluated as inhibitors of nitric oxide synthases (NOS). While the N-substitution of the acetamidine moiety with different heterocycles appears to completely destroy the activity, linking the phenyl core preserves it. Moreover, it was observed a strong dependence of the phenylacetamidines potency of action from the length of the alkyl chain that connects the aromatic ring to the acetamidine moiety.

Keywords: Nitric oxide, Nitric oxide synthase, Selective inducible NOS inhibitors, Acetamidines, heterocycles, inorganic, neurodegenerative diseases, cytokines, polysaccharides, amino acid

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Article Details

VOLUME: 8
ISSUE: 6
Year: 2012
Page: [991 - 995]
Pages: 5
DOI: 10.2174/1573406411208060991
Price: $58

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