Generic placeholder image

Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Effects of Atorvastatin on Cerebral Blood Flow in Middle-Aged Adults at Risk for Alzheimer’s Disease: A Pilot Study

Author(s): Cynthia M. Carlsson, Guofan Xu, Zhifei Wen, Jodi H. Barnet, Hanna M. Blazel, Richard J. Chappell, James H. Stein, Sanjay Asthana, Mark A. Sager, David C. Alsop, Howard A. Rowley, Sean B. Fain and Sterling C. Johnson

Volume 9, Issue 8, 2012

Page: [990 - 997] Pages: 8

DOI: 10.2174/156720512803251075

Price: $65

Abstract

Background/Aims: Hypercholesterolemia in midlife increases risk for Alzheimer’s disease (AD) and contributes to cerebrovascular dysregulation - an early finding in preclinical AD pathology. Statins improve vascular reactivity, but it is unknown if they increase regional cerebral blood flow (CBF) in individuals at risk for AD. Methods: In a randomized, controlled, double-blind pilot study, 16 asymptomatic middle-aged adults with parental history of AD were randomized to atorvastatin or placebo daily for 4 months. At baseline and month 4, regional CBF was measured using arterial spin-labeling magnetic resonance imaging and endothelial function was measured using brachial artery ultrasound. Results: At baseline, participants with low HDL-cholesterol, higher global vascular risk, and greater endothelial dysfunction had reduced regional CBF in areas of the brain related to memory and learning (all p<0.03). Using voxel-based analysis, 4 months of atorvastatin increased CBF in bilateral hippocampi, fusiform gyrus, putamen and insular cortices compared to placebo. Conclusion: In this pilot study, atorvastatin increased regional CBF in persons at risk for AD. Further research is warranted to confirm whether statins increase CBF in areas of the brain related to memory and learning and whether such perfusion changes are associated with a delay in the onset of AD. Clinical Trial Registration: http://clinicaltrials.gov Identifier: NCT00751907.

Keywords: Alzheimer’s disease, cerebral blood flow, dementia, MRI perfusion, prevention, statins, FMD, aspartate aminotransferase

« Previous

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy