Cancer-Fighting Molecules-Taxol and its Analogs

Author(s): Zhi-Yu Ni , Yong Li , Yu-Fang Wang , Si-Ming Wang , Mei Dong , Qing-Wen Shi .

Journal Name: Current Organic Chemistry

Volume 16 , Issue 17 , 2012

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Abstract:

Natural products have not only yielded new and effective drugs but have also provided insight into new mechanisms of action. Paclitaxel (Taxol) as the first promoters of tubulin polymerization plays important roles in the war against cancer and in the exploring new microtubule-binding drugs. The present review summarized the development of paclitaxel and its analogues which can be used as the precurce of synthesis of Taxol and its analogues.

Keywords: Taxol, taxol analogy, taxane, Taxus, anti-cancer, proliferation, phenotype, heredity, motherapeutic, radiotherapy

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Article Details

VOLUME: 16
ISSUE: 17
Year: 2012
Page: [2038 - 2052]
Pages: 15
DOI: 10.2174/138527212803251659
Price: $58

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