Glioblastoma multiforme (GBM) is the most common and most malignant primary brain tumor occurring
during adulthood. The incidence of GBM is nearly 5 cases per 100,000 population per year. The standard of care for
newly diagnosed GBM includes surgical resection when possible, followed by radiotherapy and concomitant and adjuvant
chemotherapy with temozolomide. Imaging modalities used in nuclear medicine, namely positron emission tomography
(PET) and single-photon emission computed tomography (SPECT) have been employed towards the evaluation of brain
tumors. Herewith, we discuss the value of the above imaging techniques in the assessment of GBM aggressiveness, in the
distinction of treatment induced necrosis from glioma recurrence, in the estimation of overall prognosis and in the
evaluation of treatment response in patients with GBM.
Keywords: Chemotherapy, glioblastoma multiforme, nuclear medicine, PET, radiotherapy, SPECT, surgery.
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