Abstract
Impaired brain connectivity is a hallmark of schizophrenia brain dysfunction. However, the effect of drug treatment and challenges on the dysconnectivity of functional networks in schizophrenia is an understudied area. In this review, we provide an overview of functional magnetic resonance imaging studies examining dysconnectivity in schizophrenia and discuss the few studies which have also attempted to probe connectivity changes with antipsychotic drug treatment. We conclude with a discussion of possible avenues for further investigation.
Keywords: Antipsychotic drug treatment, brain connectivity, fMRI, schizophrenia
Current Neuropharmacology
Title:Brain Connectivity Studies in Schizophrenia: Unravelling the Effects of Antipsychotics
Volume: 10 Issue: 3
Author(s): Ayna B. Nejad, Bjorn H. Ebdrup, Birte Y. Glenthoj and Hartwig R. Siebner
Affiliation:
Keywords: Antipsychotic drug treatment, brain connectivity, fMRI, schizophrenia
Abstract: Impaired brain connectivity is a hallmark of schizophrenia brain dysfunction. However, the effect of drug treatment and challenges on the dysconnectivity of functional networks in schizophrenia is an understudied area. In this review, we provide an overview of functional magnetic resonance imaging studies examining dysconnectivity in schizophrenia and discuss the few studies which have also attempted to probe connectivity changes with antipsychotic drug treatment. We conclude with a discussion of possible avenues for further investigation.
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Cite this article as:
B. Nejad Ayna, H. Ebdrup Bjorn, Y. Glenthoj Birte and R. Siebner Hartwig, Brain Connectivity Studies in Schizophrenia: Unravelling the Effects of Antipsychotics, Current Neuropharmacology 2012; 10 (3) . https://dx.doi.org/10.2174/157015912803217305
DOI https://dx.doi.org/10.2174/157015912803217305 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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