Current Drug Metabolism

Michael Sinz
Bristol Myers Squibb
Wallingford, CT


Impacts of Nanoparticles on Cardiovascular Diseases: Modulating Metabolism and Function of Endothelial Cells

Author(s): Jie Meng, Xian-da Yang, Lee Jia, Xing-Jie Liang and Chen Wang

Affiliation: Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology of China, Beijing 100190; P.R. China.


Endothelial cells have very important functions, one of which is their contribution to regulating molecule and nutrient exchanges between the blood and peripheral tissues. Dysfunction of endothelial cells plays an essential role in the progression of cardiovascular diseases (CVD) such as atherosclerosis and coronary heart disease. With the recent progress of nanotechnology, increasing numbers of studies have focused on the effects of nanoparticles on CVD. In this article, we review the biological characters of endothelial cells, evaluate the impacts of nanoparticles on the behavior and functions of endothelial cells, analyze advantages and disadvantages of various nanoparticles, and discuss potential applications of nanoparticles to CVD treatment.

Keywords: Endothelial cells, nanoparticles, cardiovascular diseases, Modulating, CVD, CAD, atrial fibrillation, peripheral vascular disease, arteriosclerosis, hypercholesterolemia.

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Article Details

Page: [1123 - 1129]
Pages: 7
DOI: 10.2174/138920012802850056
Price: $58