Current Drug Metabolism

Michael Sinz
Bristol Myers Squibb
Wallingford, CT


Nanoparticles Improve Biological Functions of Phthalocyanine Photosensitizers Used for Photodynamic Therapy

Author(s): Xiao Jia and Lee Jia

Affiliation: 6130 Executive Blvd. Suite 8042, Bethesda, MD 20852, USA.


Photodynamic therapy (PDT) is a new technology using photodynamic effect for disease diagnosis and treatment. It is a twostep technique involving the uptake of a photosensitizer by cancer tissue followed by light irradiation that excites the photosensitizer to produce highly reactive oxygen species, the latter execute apoptosis of cancerous cells. As a second-generation of photosensitizers, phthalocyanine demonstrates higher absorption in the 650-800nm range and short tissue accumulation compared to their first generation. However, many potent phthalocyanine photosensitizers are hydrophobic and poorly water-soluble, which limit their therapeutic applications. As a result, advanced delivery systems and different strategies are called for to improve the effectiveness of PDT. Facts have proved that using nanoparticles as carries of photosensitizers is a very promising route. Nanoparticles have the potentials to increase photosensitizers’ aqueous solubility, bioavailability and stability, and deliver photosensitizers to the target tissues. This article reviewed the commonly-used nanoparticles, including colloid gold, quantum dots, paramagnetic nanoparticles, silica-based materials, polymer-based nanoparticles, as potential delivery systems for phthalocyanine photosensitizers, and summarized the improved biological functions of phthalocyanine photosensitizers in PDT.

Keywords: Photodynamic therapy, phthalocyanine photosensitizers, nanoparticles, nanocarriers, drug delivery, Phthalocyanin, Photosensitizers, Photodynamic, Therapy, Nanobiotechnology, Langmuir-Blodgett films, pharmacokinetics, modalities.

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Article Details

Page: [1119 - 1122]
Pages: 4
DOI: 10.2174/138920012802850074