Nanoparticles Improve Biological Functions of Phthalocyanine Photosensitizers Used for Photodynamic Therapy
Xiao Jia and Lee Jia
Pages 1119-1122 (4)
Photodynamic therapy (PDT) is a new technology using photodynamic effect for disease diagnosis and treatment. It is a twostep
technique involving the uptake of a photosensitizer by cancer tissue followed by light irradiation that excites the photosensitizer to
produce highly reactive oxygen species, the latter execute apoptosis of cancerous cells. As a second-generation of photosensitizers,
phthalocyanine demonstrates higher absorption in the 650-800nm range and short tissue accumulation compared to their first generation.
However, many potent phthalocyanine photosensitizers are hydrophobic and poorly water-soluble, which limit their therapeutic applications.
As a result, advanced delivery systems and different strategies are called for to improve the effectiveness of PDT. Facts have
proved that using nanoparticles as carries of photosensitizers is a very promising route. Nanoparticles have the potentials to increase photosensitizers’
aqueous solubility, bioavailability and stability, and deliver photosensitizers to the target tissues. This article reviewed the
commonly-used nanoparticles, including colloid gold, quantum dots, paramagnetic nanoparticles, silica-based materials, polymer-based
nanoparticles, as potential delivery systems for phthalocyanine photosensitizers, and summarized the improved biological functions of
phthalocyanine photosensitizers in PDT.
Photodynamic therapy, phthalocyanine photosensitizers, nanoparticles, nanocarriers, drug delivery, Phthalocyanin, Photosensitizers, Photodynamic, Therapy, Nanobiotechnology, Langmuir-Blodgett films, pharmacokinetics, modalities.
6130 Executive Blvd. Suite 8042, Bethesda, MD 20852, USA.