Dendrimers in Cancer Therapeutics and Diagnosis
Rui Guo and Xiangyang Shi
Affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, People’s Republic of China.
Keywords: Dendrimer, anticancer drug delivery, cancer diagnosis, nanometer, Hybrid, Nanomedicine, gene regulation, dendritic branches, linear polymers, bioassemblies
Dendrimers represent a class of monodispersed synthetic macromolecules with a well defined three-dimensional structure of
nanometer dimension in which a series of layered branches regularly extend from a central core molecule. Due to their precise nanoscale
sizes, well-defined branched structures, and various surface modifications, dendrimers have been extensively investigated in a wide range
of applications in the biomedical field, particularly in the therapeutics and diagnosis of cancer. This article gives an overview of the recent
advances of dendrimers and dendrimer-based hybrid nanoparticles for cancer therapeutics and diagnosis applications.
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